Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between (...) studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice. (shrink)

We consider structural completeness in modal logics. The main result is the necessary and sufficient condition for modal logics over K4 to be hereditarily structurally complete: a modal logic λ is hereditarily structurally complete $\operatorname{iff} \lambda$ is not included in any logic from the list of twenty special tabular logics. Hence there are exactly twenty maximal structurally incomplete modal logics above K4 and they are all tabular.

The importance of communities in strengthening the ethics of international collaborative research is increasingly highlighted, but there has been much debate about the meaning of the term ‘community’ and its specific normative contribution. We argue that ‘community’ is a contingent concept that plays an important normative role in research through the existence of morally significant interplay between notions of community and individuality. We draw on experience of community engagement in rural Kenya to illustrate two aspects of this interplay: (i) that (...) taking individual informed consent seriously involves understanding and addressing the influence of communities in which individuals’ lives are embedded; (ii) that individual participation can generate risks and benefits for communities as part of the wider implications of research. We further argue that the contingent nature of a community means that defining boundaries is generally a normative process itself, with ethical implications. Community engagement supports the enactment of normative roles; building mutual understanding and trust between researchers and community members have been important goals in Kilifi, requiring a broad range of approaches. Ethical dilemmas are continuously generated as part of these engagement activities, including the risks of perverse outcomes related to existing social relations in communities and conditions of ‘half knowing’ intrinsic to processes of developing new understandings. (shrink)

The article examines the unconscious uncontrolled side of the human psyche, analyzes approaches to determining the structure of the unconscious, its constituent elements and their relationships from the point of view of the concepts of prominent psychoanalysts Z. Freud, C. Jung and J. Lacan. The significance of the "mirror stage" described by Lacan is revealed. in the understanding of human self-consciousness. Particular attention is paid to Lacan's thesis that the unconscious is, first of all, language; and it is he who (...) acts as a manifestation of a structure that has clear patterns. It is through language that we can approach understanding of the connection of the unconscious with the conscious world in the context of Lacan's definition of the triad of "real", "imaginary" and "symbolic". The purpose of the study is to show the relationship between the concepts of the structure of the unconscious and the fusion of psychoanalysis with philosophical and linguistic structuralism, which gives rise to a variety of approaches and interdisciplinary research in understanding the essence of the unconscious and interpreting social phenomena through the linguistic structures of myth. (shrink)

The article explored the fact that various bioethical principles underlie the evaluation of the patient’s status and role in therapeutic interactions in written medical documents. We have found that characterization of biomedical, social and behavioural aspects of the patient’s existence relies on such bioethical principles as obligation, truthfulness, respect for human rights and dignity, the patient’s good. A few facts of the violation of the principle of respect for human rights and dignity consisting in verbal stigmatization have been provided. Bioethical (...) perspective is also taken to evaluate the mode and extent of the patient’s involvement in a medical interaction, which are either negatively or positively assessed based on the patient’s compliance and good. (shrink)

It is argued that it is a misinterpretation of frege to construe his talk of the bedeutungen of sentences and of predicates in an ontologically innocent way.

Clustered, regularly interspaced, short palindromic repeat (CRISPR)/CRISPR‐associated protein (CRISPR/Cas) system has revolutionized genetic research in the life sciences. Four classes of CRISPR/Cas‐derived genome editing agents, such as nuclease, base editor, recombinase, and prime editor have been introduced for engineering the genomes of diverse organisms. The recently introduced prime editing system offers precise editing without many off‐target effects than traditional CRISPR‐based systems. Many researchers have successfully applied this gene‐editing toolbox in diverse systems for various genome‐editing applications. This review presents the mechanism (...) of prime editing and summarizes the details of the prime editing system applied in plants and mammalian cells for precise genome editing. We also discuss the advantages, limitations, and potential future applications of prime editing in these systems. This review enables the researcher to gain knowledge on prime editing tools and their potential applications in plants and mammalian cells. (shrink)

Rorty has been criticized for his pragmatic rationality by different thinkers like Stout, Steven carter. Here in this article our main focus is Novoa's criticism of Rorty's solution to the challenges of evidentialism (Novoa in Rorty’s Demands on Religious Belief: Looking for a Pragmatic Rationality. Retrieved October 20, 2019, from Researchgate. https://www.researchgate.net/publication/321729830_rorty's_demands_on_religious_belief_looking_for_a _pragmatic_rationality, 2017). Novoa feels that religion needs not be conversation stopper as long as it does not compromise on capabilities (Novoa, 2017). This is what he calls pragmatic rationality. He (...) takes pragmatic rationality based on capabilities. So in this article we argue against Novoa saying that capabilities are not clearly defined and hence the criteria set forth by Novoa have to be revised. The criteria set forth by him are too general, for instance world relationships, etc. The reasons for revising the criteria are too general, no unanimity in what are capabilities and even the specified capabilities are not precise. (shrink)

Книга иранского историка посвящена истории происхождения названия государства Азербайджан, истории Кавказской Албании, древнему государству существовавшему на территории современных Азербайджана, Дагестана и Армении (Нагорного Карабаха).

Nadezhnostʹ matematicheskogo dokazatelʹstva -- Nadezhnostʹ logicheskikh norm -- Ontologicheskoe obosnovanie matematiki -- Sistemnoe obosnovanie matematiki.

First Published on: 21 June 2007 To cite this Article: Ramachandran, Vilayanur S., McGeoch, Paul D., Williams, Lisa and Arcilla, Gerard (2007) 'Rapid Relief of Thalamic Pain Syndrome Induced by Vestibular Caloric Stimulation', Neurocase, 13:3, 185 - 188 To link to this article: DOI: 10.1080/13554790701450446 URL: http://dx.doi.org/10.1080/13554790701450446..

The target articles on sleep and dreaming are discussed in terms of the concept of search activity integrating different types of behavior, body resistance, REM sleep/dream functions, and the brain catecholamine system. REM sleep may be functionally sufficient or insufficient, depending on the dream scenario, the latter being more important than the physiological manifestation of REM sleep. REM sleep contributes to memory consolidation in the indirect way. [Nielsen; Revonsuo; Solms; Vertes & Eastman].